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Threehorizons.
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three doors.
Your bridge between the world and Japan's pharmaceutical & health industry.
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2023
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Care Link
Specialty Pharma × Last Mile
Delivering directly to patients
Last-mile delivery of specialty pharmaceuticals from pharmacies to patient homes. End-to-end cold chain management, adherence monitoring, and PSP integration.
Global Bridge
Import × Export
A two-way bridge between Japan and the world
Japan market entry for overseas pharma and raw materials. Global expansion for Japanese OTC and supplements. Regulatory to logistics, end-to-end.
garden
Supplement Development
From idea to product
Supplement and health food planning to manufacturing. OEM/ODM, raw material sourcing, and branding support.
Latest Insights
Healthcare insights shared by CEO Masaya Yamamoto on NewsPicks
梅毒治療薬不足 ― サプライチェーン集中リスクと政策設計の課題
The prolonged shortage of benzathine benzylpenicillin—the sole standard treatment for syphilis—laid bare a structural vulnerability in Japan's infectious disease response. A single equipment failure at a manufacturing facility translated almost immediately into nationwide clinical constraints, precisely because production is concentrated in too few sites while demand continues to rise. This is not an isolated incident; it should serve as a catalyst for rethinking the procurement and stockpiling framework for infectious disease treatments as a whole. Complicating matters further, doxycycline—the suggested alternative—is restricted to patients with penicillin allergies, leaving clinicians with little room to maneuver. The real question now is whether authorities can move swiftly on emergency measures such as expanding the approved indications for alternatives and pursuing international procurement, while also building a policy architecture that distributes manufacturing risk before the next crisis strikes.
熱中症対策の本質 ― 気温より社会制度の穴を埋めよ
The Japan Meteorological Association forecasts that broad regions—including Kanto, Tokai, Kinki, Kyushu, and Okinawa—will face 'strict alert' or even 'danger' level heat through the first half of September, and the pattern of prolonged late-summer heat is not unique to this year. Yet the core issue, in my view, lies less in temperature itself than in gaps within our social systems. As European heat waves have repeatedly demonstrated, the isolation of elderly people and the absence of welfare-check infrastructure dramatically elevate mortality risk. In Japan, a growing number of elderly people living alone have air conditioners but cannot use them effectively due to anxiety over electricity bills or difficulty operating the units—meaning installation rates alone paint a misleading picture. As this article rightly points out, nighttime heatstroke is closely tied to housing conditions and air-conditioner use, so addressing the economic and cognitive barriers that prevent that use is precisely where government and local communities must focus. Even as weather forecasting grows more sophisticated, the monitoring networks needed to translate that information into behavioral change have not kept pace. We need to deliberately design solutions that distinguish between what technology can handle and what requires human networks.
筋トレ・ゲートボールと認知症リスク低下 ― 観察研究の解釈と政策への示唆
The prospective observational findings showing a significant reduction in dementia risk associated with resistance training and gateball are intriguing, yet residual confounding—such as frequency of social participation and baseline physical and cognitive function at the time individuals took up each activity—cannot be ruled out. Those who manage to make these activities a habit may already have higher physical function and health awareness, making it difficult to fully dismiss selection bias; reading the results as straightforward evidence that 'these specific sports work' should be avoided. That said, what concerns me is how public health authorities, who currently find it difficult to drill down to the level of specific activity types in their exercise recommendations, should interpret this kind of sport-specific risk data. The differences in risk by activity type revealed in this study could serve as one input for refining future guidelines, but a single observational study is not yet sufficient to drive policy design. I would like to see reproducibility confirmed across multiple prospective and intervention studies before these findings are reflected in the way specific activities are prescribed.